Elyssa B. Margolis, PhD
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RESEARCH PAPERS AND REVIEWS

  • Margolis EB, Karkhanis AN. Dopaminergic cellular and circuit contributions to kappa opioid receptor mediated aversion 2019. Neurochemistry International, in press. PDF
  • Breton JM, Charbit AR, Snyder BJ, Fong PTK, Dias EV, Himmels P, Lock H, Margolis EB. Relative contributions and mapping of ventral tegmental area dopamine and GABA neurons by projection target in rat. 2019. J Comp Neurol. 527(5) 916-941. Altmetric score 74, Cited 4 times. PDF
  • Saunders BT, Richard JM, Margolis EB, Janak PH. Dopamine neurons create Pavlovian conditioned stimuli with circuit-defined motivational properties. 2018 Nature Neurosci 21(8) 1072-83. Cited 39 times. PDF
  • Margolis EB, Fujita W, Devi LA, Fields HL Two delta opioid receptor subtypes are functional in single ventral tegmental area neurons, and can interact with the mu opioid receptor. Neuropharmacology 2017 Sep 1;123:420-432. PMID: 28645621. Cited 9 times. PDF
  • Morales M, Margolis EB. Ventral tegmental area: cellular heterogeneity, connectivity and behaviour. Nat Rev Neurosci. 2017 Jan 05. PMID: 28053327. Cited 179 times. PDF
  • Margolis EB, Fields HL. Mu Opioid Receptor Actions in the Lateral Habenula. PLoS One. 2016; 11(7):e0159097. PMID: 27427945. Cited 15 times. PDF
  • Avegno EM, Salling MC, Borgkvist A, Mrejeru A, Whitebirch AC, Margolis EB, Sulzer D, Harrison NL. Voluntary adolescent drinking enhances excitation by low levels of alcohol in a subset of dopaminergic neurons in the ventral tegmental area. Neuropharmacology. 2016 Nov; 110(Pt A):386-95. PMID: 27475082. Cited 14 times. PDF
  • Gomes I, Bobeck EN, Margolis EB, Gupta A, Sierra S, Fakira AK, Fujita W, Müller TD, Müller A, Tschöp MH, Kleinau G, Fricker LD, Devi LA. Identification of GPR83 as the receptor for the neuroendocrine peptide PEN. Sci Signal. 2016; 9(425):ra43. PMID: 27117253. PMCID: PMC5147544. Cited 20 times. PDF 
  • Fields HL, Margolis EB. Understanding opioid reward. Trends in Neurosciences 2015 38(4):217-225. Cited 140 times. PDF
  • Margolis EB, Hjelmstad GO, Fujita W, Fields HL. Direct Bidirectional µ-Opioid Control of Midbrain Dopamine Neurons. J Neurosci. 2014 Oct 29; 34(44):14707-16. PMID: 25355223. Cited 54 times. PDF
  • Berthet A, Margolis EB, Zhang J, Hsieh I, Zhang J, Hnasko TS, Ahmad J, Edwards RH, Sesaki H, Hung EJ, Nakamura K. Loss of mitochondrial fission depletes axonal mitochondria in midbrain dopamine neurons. J Neurosci. 2014 Oct 22; 34(43):14304-17. PMID: 25339743. Cited 92 times. PDF
  • Mitchell JM, Margolis EB, Coker AR, Allen DC, Fields HL. Intra-VTA Deltorphin, But Not DPDPE, Induces Place Preference in Ethanol-Drinking Rats: Distinct DOR-1 and DOR-2 Mechanisms Control Ethanol Consumption and Reward. Alcohol Clin Exp Res. 2014 Jan; 38(1):195-203. PMID: 24033469. Cited 18 times. PDF
  • Hjelmstad GO, Xia Y, Margolis EB, Fields HL. Opioid modulation of ventral pallidal afferents to ventral tegmental area neurons. J Neurosci. 2013 Apr 10; 33(15):6454-9. PMID: 23575843. Cited 66 times. PDF
  • Volman SF, Lammel S, Margolis EB, Kim Y, Richard JM, Roitman MF, Lobo MK. New Insights into the specificity and plasticity of reward and aversion encoding in the mesolimbic system. J Neurosci 2013 33(45):17569-76. Cited 107 times. PDF
  • Margolis EB, Toy B, Himmels P, Morales M, Fields HL. Identification of rat ventral tegmental area GABAergic neurons. PLoS One. 2012; 7(7):e42365. PMID: 22860119. Cited 128 times. PDF
  • Mitchell JM, Margolis EB, Coker AR, Fields HL. Alcohol self-administration, anxiety, and cortisol levels predict changes in delta opioid receptor function in the ventral tegmental area. Behav Neurosci. 2012 Aug; 126(4):515-22. PMID: 22708955. Cited 10 times. PDF
  • Margolis EB, Mitchell JM, Hjelmstad GO, Fields HL. A novel opioid receptor-mediated enhancement of GABAA receptor function induced by stress in ventral tegmental area neurons. J Physiol. 2011 Sep 1; 589(Pt 17):4229-42. PMID: 21690191. Cited 17 times. PDF
  • Xia Y, Driscoll JR, Wilbrecht L, Margolis EB, Fields HL, Hjelmstad GO. Nucleus accumbens medium spiny neurons target non-dopaminergic neurons in the ventral tegmental area. J Neurosci. 2011 May 25; 31(21):7811-6. PMID: 21613494. Cited 181 times. PDF
  • Margolis EB, Coker AR, Driscoll JR, Lemaître AI, Fields HL. Reliability in the identification of midbrain dopamine neurons. PLoS One. 2010; 5(12):e15222. PMID: 21151605. Cited 63 times. PDF
  • Xia YF, Margolis EB, Hjelmstad GO. Substance P inhibits GABAB receptor signalling in the ventral tegmental area. J Physiol. 2010 May 1; 588(Pt 9):1541-9. PMID: 20231139. Cited 11 times. PDF
  • Dobi A, Margolis EB, Wang HL, Harvey BK, Morales M. Glutamatergic and nonglutamatergic neurons of the ventral tegmental area establish local synaptic contacts with dopaminergic and nondopaminergic neurons. J Neurosci. 2010 Jan 6; 30(1):218-29. PMID: 20053904. Cited 161 times. PDF
  • Margolis EB, Fields HL, Hjelmstad GO, Mitchell JM. Delta-opioid receptor expression in the ventral tegmental area protects against elevated alcohol consumption. J Neurosci. 2008 Nov 26; 28(48):12672-81. PMID: 19036960. Cited 80 times. PDF
  • Margolis EB, Mitchell JM, Ishikawa J, Hjelmstad GO, Fields HL. Midbrain dopamine neurons: projection target determines action potential duration and dopamine D(2) receptor inhibition. J Neurosci. 2008 Sep 3; 28(36):8908-13. PMID: 18768684. Cited 219 times. PDF
  • Fields HL, Hjelmstad GO, Margolis EB, Nicola SM. Ventral tegmental area neurons in learned appetitive behavior and positive reinforcement Annu Rev Neurosci 2007 30:289-316. Cited 493 times. PDF
  • Margolis EB, Lock H, Hjelmstad GO, Fields HL. The ventral tegmental area revisited: is there an electrophysiological marker for dopaminergic neurons? J Physiol. 2006 Dec 15; 577(Pt 3):907-24. PMID: 16959856. Cited 453 times. PDF 
  • Margolis EB, Lock H, Chefer VI, Shippenberg TS, Hjelmstad GO, Fields HL. Kappa opioids selectively control dopaminergic neurons projecting to the prefrontal cortex. Proc Natl Acad Sci U S A. 2006 Feb 21; 103(8):2938-42. PMID: 16477003. Cited 273 times.  PDF
  • Margolis EB, Hjelmstad GO, Bonci A, Fields HL. Both kappa and mu opioid agonists inhibit glutamatergic input to ventral tegmental area neurons. J Neurophysiol. 2005 Jun; 93(6):3086-93. PMID: 15615834   Topic of "Editorial Focus" in this issue. Cited 57 times.  PDF
  • Margolis EB, Hjelmstad GO, Bonci A, Fields HL. Kappa-opioid agonists directly inhibit midbrain dopaminergic neurons. J Neurosci. 2003 Nov 5; 23(31):9981-6. PMID: 14602811   "This week in the Journal" feature. Cited 245 times. PDF
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