RESEARCH PAPERS AND REVIEWS

• Margolis EB, Moulton MG, Lambeth PS, O'Meara MJ The life and times of endogenous opioid peptides: Updated understanding of synthesis, spatiotemporal dynamics, and the clinical impact in alcohol use disorder 2023. Neuropharmacology Mar 1; 225:109376. PDF
• Waung MW, Maanum KA, Driscoll JR, O'Brien C, Bryant S, Mansourian KA, Morales M, Barker DJ, Margolis EB, A diencephalic circuit for opioid analgesia but not positive reinforcement 2022. Nat Commun. Feb 9; 13(1):764. PDF
• Chakraborty S, DiBerto JF, Faouzi A, Bernhard SM, Gutridge AM, Ramsey S, Zhou Y, Provasi D, Nuthikattu N, Jilakara R, Nelson MNF, Asher WB, Eans SO, Wilson LL, Chintala SM, Filizola M, van Rijn RM, Margolis EB, Roth BL, McLaughlin JP, Che T, Sames D, Javitch JA, Majumdar S A novel mitragynine analog with low efficacy mu-opioid receptor agonism displays antinociception with attenuated adverse effects 2021. J Med Chem. Sep 10 64, 18, 13873-13892. Cited 17 times. PDF
• Miranda-Barrientos J, Chambers I, Mongia S, Liu B, Wang HL, Mateo-Semidey GE, Margolis EB, Zhang S, Morales M Ventral tegmental area GABA, glutamate, and glutamate-GABA neurons are heterogeneous in their electrophysiological and pharmacological properties 2021. European J Neurosci July 54(1)(12):4061-4084. Cited 8 times. PDF
• Margolis EB, Wallace TL, Van Orden LJ, Martin WJ Differential effects of novel kappa opioid receptor antagonists on dopamine neurons using acute brain slice electrophysiology 2020. PLoS One Dec 29;15(12):e0232864. Cited 6 times. PDF
• Driscoll JR, Wallace TL, Mansourian KA, Martin WJ, Margolis EB. Differential Modulation of Ventral Tegmental Area Circuits by the Nociceptin/Orphanin FQ System 2020. eNeuro Oct 19;7(5):ENEURO.0376-19.2020. Cited 11 times. PDF
• Fricker LD, Margolis EB, Gomes I, Devi LA. Five Decades of Research on Opioid Peptides: Current Knowledge and Unanswered Questions 2020. Molecular Pharmacology August 98(2), 96-108. Cited 58 times. PDF
• Gomes I, Sierra S, Lueptow L, Gupta A, Gouty S, Margolis EB, Cox BM, Devi LA. Biased Signaling by Endogenous Opioid Peptides 2020. PNAS May 26;117(21):11820-11828. Cited 64 times. PDF
• Waung MW, Margolis EB, Charbit AR, Fields HL. A Midbrain Circuit that Mediates Headache Aversiveness in Rats 2019. Cell Reports 28, 2739–2747. Cited 16 times. PDF
• Margolis EB, Karkhanis AN. Dopaminergic cellular and circuit contributions to kappa opioid receptor mediated aversion 2019. Neurochemistry International, 129 104504. Cited 29 times. PDF
• Breton JM, Charbit AR, Snyder BJ, Fong PTK, Dias EV, Himmels P, Lock H, Margolis EB. Relative contributions and mapping of ventral tegmental area dopamine and GABA neurons by projection target in rat. 2019. J Comp Neurol. 527(5) 916-941. Altmetric score 74, Cited 76 times. PDF
• Saunders BT, Richard JM, Margolis EB, Janak PH. Dopamine neurons create Pavlovian conditioned stimuli with circuit-defined motivational properties. 2018 Nature Neurosci 21(8) 1072-83. Cited 225 times. PDF
• Margolis EB, Fujita W, Devi LA, Fields HL Two delta opioid receptor subtypes are functional in single ventral tegmental area neurons, and can interact with the mu opioid receptor. Neuropharmacology 2017 Sep 1;123:420-432. PMID: 28645621. Cited 33 times. PDF
• Morales M, Margolis EB. Ventral tegmental area: cellular heterogeneity, connectivity and behaviour. Nat Rev Neurosci. 2017 Jan 05. PMID: 28053327. Cited 733 times. PDF
• Margolis EB, Fields HL. Mu Opioid Receptor Actions in the Lateral Habenula. PLoS One. 2016; 11(7):e0159097. PMID: 27427945. Cited 51 times. PDF
• Avegno EM, Salling MC, Borgkvist A, Mrejeru A, Whitebirch AC, Margolis EB, Sulzer D, Harrison NL. Voluntary adolescent drinking enhances excitation by low levels of alcohol in a subset of dopaminergic neurons in the ventral tegmental area. Neuropharmacology. 2016 Nov; 110(Pt A):386-95. PMID: 27475082. Cited 27 times. PDF
• Gomes I, Bobeck EN, Margolis EB, Gupta A, Sierra S, Fakira AK, Fujita W, Müller TD, Müller A, Tschöp MH, Kleinau G, Fricker LD, Devi LA. Identification of GPR83 as the receptor for the neuroendocrine peptide PEN. Sci Signal. 2016; 9(425):ra43. PMID: 27117253. PMCID: PMC5147544. Cited 60 times. PDF 
• Fields HL, Margolis EB. Understanding opioid reward. Trends in Neurosciences 2015 38(4):217-225. Cited 355 times. PDF
• Margolis EB, Hjelmstad GO, Fujita W, Fields HL. Direct Bidirectional µ-Opioid Control of Midbrain Dopamine Neurons. J Neurosci. 2014 Oct 29; 34(44):14707-16. PMID: 25355223. Cited 92 times. PDF
• Berthet A, Margolis EB, Zhang J, Hsieh I, Zhang J, Hnasko TS, Ahmad J, Edwards RH, Sesaki H, Hung EJ, Nakamura K. Loss of mitochondrial fission depletes axonal mitochondria in midbrain dopamine neurons. J Neurosci. 2014 Oct 22; 34(43):14304-17. PMID: 25339743. Cited 159 times. PDF
• Mitchell JM, Margolis EB, Coker AR, Allen DC, Fields HL. Intra-VTA Deltorphin, But Not DPDPE, Induces Place Preference in Ethanol-Drinking Rats: Distinct DOR-1 and DOR-2 Mechanisms Control Ethanol Consumption and Reward. Alcohol Clin Exp Res. 2014 Jan; 38(1):195-203. PMID: 24033469. Cited 27 times. PDF
• Hjelmstad GO, Xia Y, Margolis EB, Fields HL. Opioid modulation of ventral pallidal afferents to ventral tegmental area neurons. J Neurosci. 2013 Apr 10; 33(15):6454-9. PMID: 23575843. Cited 108 times. PDF
• Volman SF, Lammel S, Margolis EB, Kim Y, Richard JM, Roitman MF, Lobo MK. New Insights into the specificity and plasticity of reward and aversion encoding in the mesolimbic system. J Neurosci 2013 33(45):17569-76. Cited 172 times. PDF
• Margolis EB, Toy B, Himmels P, Morales M, Fields HL. Identification of rat ventral tegmental area GABAergic neurons. PLoS One. 2012; 7(7):e42365. PMID: 22860119. Cited 199 times. PDF
• Mitchell JM, Margolis EB, Coker AR, Fields HL. Alcohol self-administration, anxiety, and cortisol levels predict changes in delta opioid receptor function in the ventral tegmental area. Behav Neurosci. 2012 Aug; 126(4):515-22. PMID: 22708955. Cited 15 times. PDF
• Margolis EB, Mitchell JM, Hjelmstad GO, Fields HL. A novel opioid receptor-mediated enhancement of GABAA receptor function induced by stress in ventral tegmental area neurons. J Physiol. 2011 Sep 1; 589(Pt 17):4229-42. PMID: 21690191. Cited 27 times. PDF
• Xia Y, Driscoll JR, Wilbrecht L, Margolis EB, Fields HL, Hjelmstad GO. Nucleus accumbens medium spiny neurons target non-dopaminergic neurons in the ventral tegmental area. J Neurosci. 2011 May 25; 31(21):7811-6. PMID: 21613494. Cited 246 times. PDF
• Margolis EB, Coker AR, Driscoll JR, Lemaître AI, Fields HL. Reliability in the identification of midbrain dopamine neurons. PLoS One. 2010; 5(12):e15222. PMID: 21151605. Cited 83 times. PDF
• Xia YF, Margolis EB, Hjelmstad GO. Substance P inhibits GABAB receptor signalling in the ventral tegmental area. J Physiol. 2010 May 1; 588(Pt 9):1541-9. PMID: 20231139. Cited 19 times. PDF
• Dobi A, Margolis EB, Wang HL, Harvey BK, Morales M. Glutamatergic and nonglutamatergic neurons of the ventral tegmental area establish local synaptic contacts with dopaminergic and nondopaminergic neurons. J Neurosci. 2010 Jan 6; 30(1):218-29. PMID: 20053904. Cited 239 times. PDF
• Margolis EB, Fields HL, Hjelmstad GO, Mitchell JM. Delta-opioid receptor expression in the ventral tegmental area protects against elevated alcohol consumption. J Neurosci. 2008 Nov 26; 28(48):12672-81. PMID: 19036960. Cited 100 times. PDF
• Margolis EB, Mitchell JM, Ishikawa J, Hjelmstad GO, Fields HL. Midbrain dopamine neurons: projection target determines action potential duration and dopamine D(2) receptor inhibition. J Neurosci. 2008 Sep 3; 28(36):8908-13. PMID: 18768684. Cited 269 times. PDF
• Fields HL, Hjelmstad GO, Margolis EB, Nicola SM. Ventral tegmental area neurons in learned appetitive behavior and positive reinforcement Annu Rev Neurosci 2007 30:289-316. Cited 656 times. PDF
• Margolis EB, Lock H, Hjelmstad GO, Fields HL. The ventral tegmental area revisited: is there an electrophysiological marker for dopaminergic neurons? J Physiol. 2006 Dec 15; 577(Pt 3):907-24. PMID: 16959856. Cited 603 times. PDF
• Margolis EB, Lock H, Chefer VI, Shippenberg TS, Hjelmstad GO, Fields HL. Kappa opioids selectively control dopaminergic neurons projecting to the prefrontal cortex. Proc Natl Acad Sci U S A. 2006 Feb 21; 103(8):2938-42. PMID: 16477003. Cited 349 times. PDF
• Margolis EB, Hjelmstad GO, Bonci A, Fields HL. Both kappa and mu opioid agonists inhibit glutamatergic input to ventral tegmental area neurons. J Neurophysiol. 2005 Jun; 93(6):3086-93. PMID: 15615834 Topic of "Editorial Focus" in this issue. Cited 94 times. PDF
• Margolis EB, Hjelmstad GO, Bonci A, Fields HL. Kappa-opioid agonists directly inhibit midbrain dopaminergic neurons. J Neurosci. 2003 Nov 5; 23(31):9981-6. PMID: 14602811 "This week in the Journal" feature. Cited 318 times. PDF